Optional Studies
Alongside the core registry, PARANOIA will host optional studies to run in parallel. These will require additional datasets for time-limited periods. If you upload data to these optional studies for a set number of cases, you will be eligible for authorship.
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Please see below for current and upcoming optional study protocols.
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Live studies
There is currently no consensus on the ideal strategy for prevention, mitigation and management for CR-POPF following pancreaticoduodenctomy (PD). Heterogeneity exists within practice worldwide between surgeons, training and their experience.
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Aim: To assess the outcome of key mitigation strategies on pancreaticoduodenectomy on CR-POPF.
A recent systematic review in distal pancreatectomy has demonstrated that diabetes was a protective factor against CR-POPF. This could be explained by association of diabetes and the replacement of pancreatic parenchymal tissue with fibrosis which may protect against POPF. This has not been tested in PD
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Aim: To assess the impact of diabetes on incidence of CR-POPF
Acinar cell volume at the neck margin (fat/collagen/acinar cells) has been associated with postoperative pancreatitis and POPF, the theory being that the higher the acinar cell count the higher the likelihood of their occurrence.
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Aim
To evaluate the changes in pancreatic histological composition by comparing acinar cell score between patients who develop POH, PPAP and POPF and whether this change can be predictive.
To evaluate the effect of neoadjuvant chemotherapy on the acinar cell volume.
Post-pancreatectomy acute pancreatitis PPAP has recently been defined by the ISGPS group as an acute inflammatory condition of the pancreatic remnant beginning within the first three postoperative days following a partial pancreatic resection. It has been suggested that PPAP can lead to significant morbidity and risk of mortality. However, its incidence and the clinical outcome among patients with hyperamylaesemia after partial pancreatic resection is variable.
Aim
To assess the incidence of PPAP using ISGPS definitions and quantify and stratify its outcomes