Optional Studies
OPEN FOR DATA COLLECTION!!!
Three optional studies are now open for data collection:
1) Impact on preoperative glycaemic control and diabetes on POPF after pancreaticoduodenectomy
2) The central role of the acinar cell in post-operative pancreatitis and fistula
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3) Validation of the ISGPS guidelines for post-pancreatectomy acute pancreatitis (PPAP) and assessment of outcomes
These studies will run in parallel to the registry. There is no obligation to partake in these studies however contribution to one or more of these studies will give you collaborative authorship in the subsequent publications of the dataset. Some of the data fields are common to numerous studies thus shortening the total volume of data required to participate in these studies.
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Details of each optional study can be found below.
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Data can be entered by the surgeon or by their meta-data team. Collaborative authorship will be given to both the surgeon and person/s entering the data.
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Impact on preoperative glycaemic control and diabetes on POPF after PD
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Aim:
To evaluate whether diabetes and duration of the disease according to WHO criteria impacts on the development of POPF after PD
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Study specific inclusion criteria
Preoperative HbA1c – this can be taken at any time before the operation commences and can be taken either as part of preoperative assessment or in the anaesthetic room.
The central role of the acinar cell in post-operative pancreatitis and fistula
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Aim:
To evaluate the changes in pancreatic histological composition by comparing acinar cell score between patients who develop POH, PPAP and POPF and whether this change can be predictive.
To evaluate the effect of neoadjuvant chemotherapy on the acinar cell volume.
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Study specific inclusion criteria
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Acinar cell volume scoring of frozen section margin
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PDAC
Validation of the ISGPS guidelines for post-pancreatectomy acute pancreatitis (PPAP) and assessment of outcomes
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Aim:
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To quantify the incidence of PPAP using the ISGPS definition through PARANOIA Platform
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To quantify and stratify clinical outcomes among patients with PPAP, specifically with respect to POPF, DGE, PPH, CD3+ morbidity and 30 and 90 day mortality
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To assess the risk factors associated with PPAP
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Study specific inclusion criteria
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Serum amylase POD 0-3
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CT abdo/pelvis performed for any indication POD 2-7
Who can enter the data?
If you are entering the data, then all optional studies will automatically appear on your project page.
If you have trainees/ data managers who will enter the data on your behalf, they must register using the following link: https://bistc.redcap.bham.ac.uk/surveys/?s=Y38MX4CCPN4NT9EH
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Authorship
As per original PARANOIA, the collaborative model of authorship will be followed and all contributors, registered consultants and their meta-data team, will be recognised. Collaborative authorship will be PubMed-indexed under the name ‘PARANOIA Study Group’.